Publications

Selected Publications

A Non-Perturbative Molecular Grafting Strategy for Stable and Potent Therapeutic Peptide Ligands

Sicinski, K. M.; Montanari, V.; Raman, V. S.; Doyle, J. R.; Harwood, B. N.; Song, Y.-C.; Fagan, M. P.; Rios, M.; Haines, D. R.; Kopin, A. S.; Beinborn, M.; Kumar, K. ACS Cent. Sci. 2021, 7, 454-466. [PubMed]

Exploiting Existing Molecular Scaffolds for Long-Term COVID Treatment

Kumar, K.; Lupoli, T. ACS Med. Chem. Lett. 2020, 11, 1357-1360. [PubMed]

Discovery of Peptide Antibiotics Composed of D-Amino Acids.

Adailgil, E.; Patil, K.; Rodenstein, M.; Kumar, K. ACS Chem. Biol. 2019, 14, 1498-1506. [PubMed]

2021 – 2019

A Non-Perturbative Molecular Grafting Strategy for Stable and Potent Therapeutic Peptide Ligands

Chemical Biology and Supramolecular Chemistry of Fluorinated Molecules.

Sicinski, K.; Montanari, V.; Kumar, K. Frontiers in Organofluorine Chemistry. Ojima, I. Ed., World Scientific 2020. 561-584.

Exploiting Existing Molecular Scaffolds for Long-Term COVID Treatment

Kumar, K.; Lupoli, T. ACS Med. Chem. Lett. 2020, 11, 1357-1360.

Discovery of Peptide Antibiotics Composed of D-Amino Acids.

Adailgil, E.; Patil, K.; Rodenstein, M.; Kumar, K. ACS Chem. Biol. 2019, 14, 1498-1506. [PubMed]

2016 – 2014

De Novo Design of Protein Mimics of B-DNA.

Yüksel, D.; Bianco, P. R.; Kumar, K. Mol. Biosyst. 2016, 12 (1), 169–177. [PubMed]

Designing Convergent Chemistry Curricula.

Charkoudian, L. K.; Sampson, N. S.; Kumar, K.; Kritzer, J. A. Nat. Chem. Biol. 2016, 12, 382. [PubMed]

Novel Probes Establish MrgprX1 Variants as Loss and Gain of Function Receptors.

Heller, D.; Doyle, J. R.; Raman, V. S.; Beinborn, M.; Kumar, K.; Kopin, A. S. J. Pharmacol. Exp. Ther. 2015, 356 (2), 276-283. [PubMed]

Sialidases as Regulators of Bioengineered Cellular Surfaces.

Zamora, C. Y.; Ryan, M. J.; d’Alarcao, M.; Kumar, K. Glycobiology 2015, 25 (7), 784–791. [PubMed]

Total Synthesis of Trifluorobutyryl-Modified, Protected Sialyl Lewis X by a Convergent [2+2] Approach.

Akçay, G.; Ramphal, J. Y.; d’Alarcao, M.; Kumar, K. Tetrahedron Lett. 2015, 56 (1), 109–114. [PubMed]

A Two-Step Strategy to Enhance Activity of Low Potency Peptides.

Doyle, J. R.; Harwood, B. N.; Krishnaji, S. T.; Krishnamurthy, V. M.; Lin, W.-E.; Fortin, J.-P.; Kumar, K.; Kopin, A. S. PLoS One 2014, 9 (11), e110502. [PubMed]

An Air- and Water-Stable Iodonium Salt Promoter for Facile Thioglycoside Activation.

Chu, A.-H. A.; Minciunescu, A.; Montanari, V.; Kumar, K.; Bennett, C. S. Org. Lett. 2014, 16 (6), 1780–1782. [PubMed]

Development of a Membrane-Anchored Chemerin Receptor Agonist as a Novel Modulator of Allergic Airway Inflammation and Neuropathic Pain.

Doyle, J. R.; Krishnaji, S. T.; Zhu, G.; Xu, Z.-Z.; Heller, D.; Ji, R.-R.; Levy, B. D.; Kumar, K.; Kopin, A. J. Biol. Chem. 2014, 289 (19), 13385–13396. [PubMed]

2013 – 2011

Colocalization of the Ganglioside GM1 and Cholesterol Detected by Secondary Ion Mass Spectrometry.

Lozano, M. M.; Liu, Z.; Sunnick, E.; Janshoff, A.; Kumar, K.; Boxer, S. G. J. Am. Chem. Soc. 2013, 135 (15), 5620–5630. [PubMed]

Fluorogenic Sialic Acid Glycosides for Quantification of Sialidase Activity upon Unnatural Substrates.

Zamora, C. Y.; d’Alarcao, M.; Kumar, K. Bioorg. Med. Chem. Lett. 2013, 23 (11), 3406–3410. [PubMed]

Fluorination in the Design of Membrane Protein Assemblies.

Krishnamurthy, V. M.; Kumar, K. Methods Mol. Biol. 2013, 1063, 227-243. [PubMed]

Ligand-Induced Protein Mobility in Complexes of Carbonic Anhydrase II and Benzenesulfonamides with Oligoglycine Chains.

Krishnamurthy, V. M.; Raman, V. S.; Mowery, R. A.; Hentz, M.; Baleja, J. D.; Shaw, B. F.; Kumar, K. PLoS One 2013, 8 (3), e57629. [PubMed]

Cross-Strand Interactions of Fluorinated Amino Acids in β-Hairpin Constructs.

Clark, G. A.; Baleja, J. D.; Kumar, K. J. Am. Chem. Soc. 2012, 134 (43), 17912–17921. [PubMed]

A Model System for Cell Adhesion Mediated by Weak Carbohydrate-Carbohydrate Interactions.

Lorenz, B.; de Cienfuegos, L. Á.; Oelkers, M.; Kriemen, E.; Brand, C.; Stephan, M.; Sunnick, E.; Yüksel, D.; Kalsani, V.; Kumar, K.; et al. J. Am. Chem. Soc. 2012, 134 (7), 3326–3329. [PubMed]

Chemical Biology Using Fluorinated Building Blocks.

Zamora, C. Y.; Dafik, L.; Kumar, K. in Supramolecular Chemistry: From Molecules to Nanomaterials. Gale, P. A. and Steed, J. W. Eds., John Wiley & Sons 2012, Chichester, UK, 1947-1964.

2010 – 2008

β-Peptide Bundles with Fluorous Cores.

Molski, M. A.; Goodman, J. L.; Craig, C. J.; Meng, H.; Kumar, K.; Schepartz, A. J. Am. Chem. Soc. 2010, 132 (11), 3658–3659. [PubMed]

Modulation of Cellular Adhesion by Glycoengineering.

Dafik, L.; d’Alarcao, M.; Kumar, K.J. Med. Chem. 2010, 53 (10), 4277–4284. [PubMed]

Trifluoromethyl Derivatization of the Ganglioside, GM1.

Liu, Z.; Kumar, K. Synthesis. 2010, 1905–1908.

A New Paradigm for Protein Design and Biological Self-Assembly.

Akçay, G.; Kumar, K. J. Fluor. Chem. 2009, 130 (12), 1178–1182. [PebMed]

Fluorinated Lipid Constructs Permit Facile Passage of Molecular Cargo into Living Cells.

Dafik, L.; Kalsani, V.; Leung, A. K. L.; Kumar, K. J. Am. Chem. Soc. 2009, 131 (34), 12091–12093. [PubMed]

Protein Design Using Non-Canonical Amino Acids.

Yüksel,D.; Pamuk, D.; Ivanova, Y.; Kumar, K. in Protein Engineering and Design Park, S.; Cochran, J. Eds.,Taylor & Francis 2009, 205-222.

Lipopeptides Derived from HIV and SIV Mimicking the Prehairpin Intermediate of gp41 on Solid Supported Lipid Bilayers.

Schuy, S.; Schäfer, E.; Yoder, N. C.; Kumar, K.; Vogel, R.; Janshoff, A. J. Struct. Biol. 2009, 168 (1), 125–136. [PubMed]

Fluorinated Amino Acids and Biomolecules in Protein Design and Chemical Biology.

Meng, H.; Clark, G. A.; Kumar, K. Fluorine in Medicinal Chemistry and Chemical Biology. Ojima, I. and Taguchi, T. Eds., John Wiley & Sons 2009, 411-446.

Engineering and Characterization of a Single Chain Surrogate Light Chain Variable Domain.

Morstadt, L.; Bohm, A.; Yüksel, D.; Kumar, K.; Stollar, B. D.; Baleja, J. D. Protein Sci. 2009, 17 (3), 458–465. [PubMed]

Biosynthesis and Stability of Coiled-Coil Peptides Containing (2S,4R)-5,5,5-Trifluoroleucine and (2S,4S)-5,5,5-Trifluoroleucine.

Montclare, J. K.; Son, S.; Clark, G. A.; Kumar, K.; Tirrell, D. A. ChemBioChem 2008, 10 (1), 84–86. [PubMed]

Coiled-Coil Lipopeptides Mimicking the Prehairpin Intermediate of Glycoprotein gp41.

Schuy, S.; Schäfer, E.; Yoder, N. C.; Hobe, S.; Kumar, K.; Vogel, R.; Janshoff, A. Angew. Chemie Int. Ed. 2008, 48 (4), 751–754. [PubMed]

Influence of Selective Fluorination on the Biological Activity and Proteolytic Stability of Glucagon-like Peptide-1.

Meng, H.; Krishnaji, S. T.; Beinborn, M.; Kumar, K. J. Med. Chem. 2008, 51 (22), 7303–7307. [PubMed]

Fluorination of Mammalian Cell Surfaces via the Sialic Acid Biosynthetic Pathway.

Dafik, L.; d’Alarcao, M.; Kumar, K. Bioorg. Med. Chem. Lett. 2008, 18 (22), 5945–5947. [PubMed]

Structure and Thermotropic Phase Behavior of Fluorinated Phospholipid Bilayers: A Combined Attenuated Total Reflection FTIR Spectroscopy and Imaging Ellipsometry Study.

Schuy, S.; Faiss, S.; Yoder, N. C.; Kalsani, V.; Kumar, K.; Janshoff, A.; Vogel, R. J. Phys. Chem. B 2008, 112 (28), 8250–8256. [PubMed]

Peptide Tertiary Structure Nucleation by Side-Chain Crosslinking with Metal Complexation and Double “Click” Cycloaddition.

Torres, O.; Yüksel, D.; Bernardina, M.; Kumar, K.; Bong, D. ChemBioChem 2008, 9 (11), 1701–1705. [PubMed]

2007 – 2005

Antimicrobial Activity and Protease Stability of Peptides Containing Fluorinated Amino Acids.

Meng, H.; Kumar, K. J. Am. Chem. Soc. 2007, 129 (50), 15615–15622. [PubMed]

Nanoscale Patterning in Mixed Fluorocarbon−Hydrocarbon Phospholipid Bilayers.

Yoder, N. C.; Kalsani, V.; Schuy, S.; Vogel, R.; Janshoff, A.; Kumar, K. J. Am. Chem. Soc. 2007, 129 (29), 9037–9043. [PubMed]

The Role of Conserved Histidines in the Structure and Stability of Human Papillomavirus Type 16 E2 DNA-Binding Domain.

Bose, K.; Yoder, N. C.; Kumar, K.; Baleja, J. D. Biochemistry 2007, 46 (5), 1402–1411. [PubMed]

Fluorinated Amino Acids and Reagents in Protein Design and Biomolecule Separation.

Meng, H.; Kalsani, V.; Kumar, K. In Current Fluoroorganic Chemistry; ACS Symposium Series; American Chemical Society, 2007; 949, 31–487.

Bioorthogonal Noncovalent Chemistry: Fluorous Phases in Chemical Biology.

Yoder, N. C.; Yüksel, D.; Dafik, L.; Kumar, K.Curr. Opin. Chem. Biol. 2006, 10 (6), 576–583. [PubMed]

Fluorinated Interfaces Drive Self-Association of Transmembrane α Helices in Lipid Bilayers.

Naarmann, N.; Bilgiçer, B.; Meng, H.; Kumar, K.; Steinem, C. Angew. Chemie Int. Ed. 2006, 45 (16), 2588–2591. [PubMed]

A Fluorous Capping Strategy for Fmoc-Based Automated and Manual Solid-Phase Peptide Synthesis.

Montanari, V.; Kumar, K. European J. Org. Chem. 2006, 4, 874–877.

Selective Protein−Protein Interactions Driven by a Phenylalanine Interface.

Yoder, N. C.; Kumar, K. J. Am. Chem. Soc. 2006, 128 (1), 188–191. [PubMed]

Enabling Routine Fluorous Capping in Solid Phase Peptide Synthesis.

Montanari, V.; Kumar, K. J. Fluor. Chem. 2006, 127 (4), 565–570.

Controlling Association of Vesicle Embedded Peptides by Alteration of the Physical State of the Lipid Matrix.

Naarmann, N.; Bilgiçer, B.; Kumar, K.; Steinem, C. Biochemistry 2005, 44 (13), 5188–5195. [PubMed]

2004 – 2000

De Novo Design of Defined Helical Bundles in Membrane Environments.

Bilgiçer, B.; Kumar, K. Proc. Natl. Acad. Sci. U. S. A. 2004, 101 (43), 15324-15329. [PubMed]

Alternative Translations of a Single RNA Message: An Identity Switch of (2S,3R)-4,4,4-Trifluorovaline between Valine and Isoleucine Codons.

Wang, P.; Fichera, A.; Kumar, K.; Tirrell, D. A. Angew. Chemie Int. Ed. 2004, 43 (28), 3664–3666. [PubMed]

A Simple and Efficient Method for the Resolution of All Four Diastereomers of 4,4,4-Trifluorovaline and 5,5,5-Trifluoroleucine.

Xing, X.; Fichera, A.; Kumar, K. J. Org. Chem. 2002, 67 (5), 1722–1725. [PubMed]